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CODE BLUE: The Importance of Integrating Care for Maternal Health and Non-Communicable Disease

鈥淣on-communicable diseases have been the leading cause of death for women for at least the past 30 years but are often underreported and undertreated,鈥� said Priya Kanayson, Policy and Advocacy Manager at听听at a recent Wilson Center听event听on the impact of non-communicable diseases (NCDs) on maternal health. The event marked the official launch of the Maternal Health Initiative鈥檚听, developed in partnership with听, a business of Merck KGaA, Darmstadt, Germany. Globally, in 2018, 73 percent of deaths among women were due to NCDs, amounting to 18 million women of reproductive age dying per year due to NCDs. The compounding effects of NCDs complicate women鈥檚 experiences in many unseen ways, and the rise and gravity of NCDs pose a growing and often overlooked challenge to maternal health worldwide.

Maternal mortality has听, but there is still a long way to go, said moderator Dr. Ana Langer, Director of the听听and Professor of the Practice of Public Health at Harvard鈥檚 T.H. Chan School of Public Health. While the global number of maternal deaths has declined by 35 percent, the vast majority of deaths occur in sub-Saharan Africa and South Asia. The United States is the only high-income country experiencing an increase in maternal mortality, although many of the deaths could be averted. About every 12 hours, a woman dies due to complications resulting from pregnancy, and more than 60 percent of those are preventable, said Dr. Lisa Waddell, Senior Vice President of Maternal Child Health and NICU Innovation and Impact Deputy Medical Director at听. While it is important to discuss how the causes of maternal mortality and morbidity are distributed, it is extremely difficult to collect and measure data on different causes. A major issue to address, Dr. Langer said, is the role of indirect causes, including NCDs, on maternal mortality and morbidity.

Multiple Medical Conditions

It is important to look at 鈥減regnancy as a window鈥� on future health, said Charlotte Warren, Director of the听听and Maternal and Newborn Health Portfolio Lead at听. A common thread identified across the main NCDs discussed鈥攃ardiovascular disease, diabetes, hypertension, chronic respiratory disease, multiple sclerosis, thyroid disease, mental health, and cancer鈥攚as the prevalence of comorbidities and multiple morbidities. Cardiovascular disease, a leading cause of maternal death in the United States, is associated with a cycle of gestational and Type II diabetes, another common NCD in pregnancy, and obesity, a common risk factor across all NCDs, said Dr. Wanda Nicholson, Director of the听听and Professor of Obstetrics and Gynecology at UNC-Chapel Hill and Immediate Past Fellow-at-Large with the听.

Obesity before pregnancy can lead to hypertension, obesity, and glucose intolerance during and after pregnancy. This increases the risk of cardiovascular disease and diabetes during and after pregnancy, across a woman鈥檚 lifespan. Hypertensive disorders in pregnancy, another leading cause of maternal and newborn death, is associated with long-term risk of cardiovascular disease, said Warren. Hypertension leads to over 70,000 maternal deaths and 500,000 newborn deaths globally each year. Pre-eclampsia, a common hypertensive disorder, is associated with a 3.7-fold increase in future cardiovascular disease and stroke.

Mental health disorders are common co-morbidities of other NCDs. Between 18 to 25 percent of women living in low- and middle-income countries experience depression, said Kanayson. One in three cancer patients in the United States experience mental or emotional stress, according to the National Cancer Institute, and 40 percent specifically experience anxiety disorders. Studies show women are more likely to develop anxiety and depression in the first year after childbirth than any other time of life. 听

Integrated Solutions

鈥淲e know that a third of maternal deaths occur in the postpartum period,鈥� Dr. Nicholson said. This postpartum period of six to twelve weeks is relatively short compared to the nine months of pregnancy. Successful and comprehensive programs and interventions to prevent maternal mortality and morbidity during and after pregnancy are needed. While programs to address NCDs within maternal health are becoming more common in the United States, few programs take this integrated approach globally.

One that does is Population Council鈥檚 Ending Eclampsia project, a program funded by the U.S. Agency for International Development (USAID) to expand access to proven, underutilized interventions, tools, and resources to prevent detect early, and treat pre-eclampsia and eclampsia. In addition to addressing hypertensive disorders for pregnant women, said Warren, Ending Eclampsia works with women鈥檚 groups in-country to improve health literacy around successful treatment and prevention for hypertensive disorders in pregnancy. In the United States, March of Dimes has seen success in programs like Supportive Pregnancy Care, a model for group prenatal care that has increased support for mothers through group prenatal care to reduce preterm birth.

NCD Alliance has worked to integrate NCDs and reproductive and maternal health, notably with the Healthy Caribbean Coalition, an organization dedicated to NCD prevention and control through civil society involvement. NCD Alliance implemented cervical cancer screenings in six countries and trained educators to talk about family planning as well as NCD risk factor education, says Kanayson. 听

Spotting Heart Disease

The American College of Obstetricians and Gynecologists has recently implemented several programs to address cardiovascular disease within maternal health, said Dr. Nicholson. The Alliance for Innovation on Maternal Health Program (AIM) is funded by the Department of Health and Human Services to prevent maternal mortality and morbidity by working within hospital facilities, professional groups, and national public health programs. The AIM program has also developed collaborations among perinatal care providers and promoted maternity safety bundles, a set of best practices specific to individual NCDs and other causes of maternal mortality and morbidity. These maternity safety bundles revolve around the 鈥渇our R鈥檚鈥�: readiness, recognition, response, and reporting. Additionally, ACOG has recently partnered with the American Heart Association to release a call to action to develop best practices to recognize cardiovascular disease early and throughout each stage of pregnancy.

Breaking Down Care Silos

A pilot program Dr. Nicholson launched at UNC-Chapel Hill called 鈥淗ealthy Transitions鈥� seeks to create a new and innovative model of care to increase surveillance of new mothers and integrate interventions for dietary changes, physical activity, and postpartum depression with women鈥檚 primary care. Promoting interventions such as these from a broader lens is one step towards breaking down the silos between NCDs and maternal health in primary care settings.

It is also important that programs address misconceptions around less common NCDs, such as multiple sclerosis (MS). Research shows that while there is a听听during pregnancy, the postpartum period is associated with an听听in women living with MS. EMD Serono鈥檚 upcoming Family Planning Resource Center seeks to address the misconceptions around MS and fertility and serve as a resource for women with MS who want to start a family, said Terrie Livingston, Head of Patient Outcomes & Solutions for Neurology and Immunology and Medical Affairs and Multiple Sclerosis Patient Advocate at EMD Serono. Shortly after the birth of her second son, Livingston herself began experiencing symptoms of MS that went undiagnosed for two years, such as fatigue, cognitive issues like loss of short-term memory, hearing loss, vertigo, and trouble breastfeeding. Often, providers do not see these symptoms as a sign of MS, as they are also common features in the postpartum period for women.

Because of multiple misconceptions, women living with MS face stigma and often are told they should not start a family. Despite this, women with MS are having children and in fact, pregnancy rates among women with MS are higher today than those for women without MS. 鈥淚 think there is a big opportunity to provide education鈥� to women living with MS and their providers around planning for a family, said Livingston.

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CODE BLUE: Addressing NCDs in Maternal Health Starts with Increasing Access and Reducing Disparity

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We鈥檝e got a crisis impacting our mothers and a crisis impacting our babies, said Dr. Lisa Waddell, Senior Vice President of Maternal Child Health and NICU Innovation and Impact Deputy Medical Director at the听,听at a recent Wilson Center听event听launching the Maternal Health Initiative鈥檚听, developed in partnership with听, a business of Merck KGaA, Darmstadt, Germany. She was referring to non-communicable diseases (NCDs), which impact maternal health in the United States and globally. NCDs kill 18 million women of reproductive age each year, accounting for two in every three deaths among women.

Lack of Access: Maternity Care Deserts

In the United States, a lack of care poses a problem. Some 5 million women currently live in 鈥渕aternity care deserts,鈥� counties where no hospital offers obstetric services and where no maternal health providers work. 鈥淲hen you鈥檙e talking about the rise of diabetes and the rise of chronic health conditions鈥攁nd then women are not able to get that care before pregnancy, can鈥檛 get that care during pregnancy鈥攊t should be no surprise that we鈥檝e got these challenges,鈥� said Dr. Waddell.

Barriers to accessing healthcare increase the risk of undiagnosed cardiovascular disease and other NCDs in pregnant women, said Dr. Wanda Nicholson, Director of the听听and Professor of Obstetrics and Gynecology at UNC-Chapel Hill and Immediate Past Fellow-at-Large with the听.

Inequity in access is also a global problem. For example, in target countries for the听, women who lack of access to blood pressure monitors face increased risk of pre-eclampsia and postpartum hemorrhage, said Charlotte Warren, Director of the Ending Eclampsia Project and Maternal and Newborn Health Portfolio Lead at听. Women in the project often had trouble getting the right information on how to prevent and treat NCDs. 鈥淭hey鈥檙e really not getting the care they should,鈥� said Warren.

Disparities in Maternal Health

Lack of access to maternity care is often exacerbated by racial disparities in maternal health. In the United States, African American women are听听to die from pregnancy and childbirth-related causes than white women. The prevalence of NCDs in the United States reflects these disparities. For example, African American women are three times more likely to die from cardiovascular disease than white women. And the maternal mortality rate for American Indian/Alaska Native women is听听than white women鈥檚.

Maternal mortality is just the tip of the iceberg, said Dr. Waddell. Under the iceberg, underlying determinants like racism, systemic barriers in the health system, differences in economic stability, and different environmental exposures contribute to disparities in health outcomes. These determinants also contribute to gender disparities within the overall burden of NCDs. For example, in 2016, 1.5 million women died due to respiratory conditions, said Priya Kanayson, Policy and Advocacy Manager at听. Globally, women and girls are exposed to more indoor air pollution due to harmful cooking materials, which contributes to higher rates of respiratory disease. Poor treatment from a human relations standpoint can also lead to worse health.听, for example, can contribute to negative birth outcomes and delay diagnosing symptoms of complications related to NCDs, said Warren.

Medical Mystery

Sometimes simply getting a correct diagnosis can be an uphill battle. For two years, Terrie Livingston, Head of Patient Outcomes & Solutions for Neurology and Immunology and Medical Affairs and Multiple Sclerosis Patient Advocate at EMD Serono, suffered from mysterious symptoms. After the birth of her second son, the symptoms intensified. 鈥淚 had this profound fatigue that I didn鈥檛 have with my first child, where I couldn鈥檛 even move off the couch,鈥� she said. 鈥淎nd it took every effort for me to be able to breastfeed my child.鈥�

After experiencing short-term memory lapses, hearing problems, and vertigo, she went to see her doctor. Doctors first misdiagnosed her and treated her accordingly, but her symptoms persisted and worsened. Her whole right side became weak and it became hard to walk. Her doctors did not think that she had Multiple Sclerosis (MS), because she is not the typical MS patient, said Livingston, who is Asian American. MS was once thought to primarily affect white women, but African American women now have the highest rate of MS in the United States. In addition, the symptoms of MS are often common in otherwise healthy postpartum women, so providers often do not see them as a sign of something more, like MS.

Priorities Should Address Underlying Determinants

To tackle the maternal health crisis and address the impact of NCDs on maternal health, it is important to make maternity care more accessible to all people, said Dr. Waddell. Advocates in the United States have pushed to expand Medicaid insurance coverage for women from 60 days to one full year following pregnancy. Women who have a higher risk of developing cardiovascular conditions or other NCDs following pregnancy should be under continued surveillance and treatment past the first postpartum visit through one full year after childbirth, said Dr. Nicholson. And collaboration in maternal health should go beyond the 鈥淥B/GYN world鈥� and include midwives and nurse practitioners, she said, especially in rural areas and 鈥渕aternity care deserts.鈥�

In order to address social norms and racial disparities in health outcomes, we need to start with the social determinants of health, said Dr. Nicholson. Health systems should also prioritize听听and听听training for providers to reduce the barriers that minority women face in the healthcare system and improve health outcomes. Globally, more work needs to be done to improve women鈥檚 experiences in healthcare settings, said Warren. 听

Taking a Life-Course Perspective

Non-communicable diseases can have an 鈥渋ntergenerational effect,鈥� said Kanayson. Children of women with NCDs face a higher risk of developing NCDs throughout their own lifespans. In order to fully address the impact of NCDs on maternal health, we need to make an effort to look further upstream to focus on interventions to reduce NCD risk factors even prior to conception, said Dr. Nicholson. A prevention-based model rather than a treatment-based model would address NCDs before they cause complications in pregnancy or later in life, the panelists said.

Women should be the center of care, said Warren. 鈥淭hey should be treated as individuals. And it doesn鈥檛 matter who they are, what they are, or where they come from, but we really need to focus on the woman and her lifestyle, and how to help her have a healthy life.鈥�

Written by Deekshita Ramanarayanan, edited by Sandra Yin

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